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Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity.
Petersen MC, Smith GI, Palacios HH, Farabi SS, Yoshino M, Yoshino J, Cho K, Davila-Roman VG, Shankaran M, Barve RA, Yu J, Stern JH, Patterson BW, Hellerstein MK, Shulman GI, Patti GJ, Klein S. Petersen MC, et al. Cell Metab. 2024 Apr 2;36(4):745-761.e5. doi: 10.1016/j.cmet.2024.03.002. Cell Metab. 2024. PMID: 38569471 Free article.
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease.
Srivastava SP, Zhou H, Shenoi R, Morris M, Lainez-Mas B, Goedeke L, Rajendran BK, Setia O, Aryal B, Kanasaki K, Koya D, Inoki K, Dardik A, Bell T 3rd, Fernández-Hernando C, Shulman GI, Goodwin JE. Srivastava SP, et al. Sci Adv. 2024 Dec 6;10(49):eadn6068. doi: 10.1126/sciadv.adn6068. Epub 2024 Dec 4. Sci Adv. 2024. PMID: 39630889 Free PMC article.
Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
Sakuma I, Gaspar RC, Luukkonen PK, Kahn M, Zhang D, Zhang X, Murray S, Golla JP, Vatner DF, Samuel VT, Petersen KF, Shulman GI. Sakuma I, et al. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2312666120. doi: 10.1073/pnas.2312666120. Epub 2023 Dec 21. Proc Natl Acad Sci U S A. 2023. PMID: 38127985 Free PMC article.
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
Mutlu B, Sharabi K, Sohn JH, Yuan B, Latorre-Muro P, Qin X, Yook JS, Lin H, Yu D, Camporez JPG, Kajimura S, Shulman GI, Hui S, Kamenecka TM, Griffin PR, Puigserver P. Mutlu B, et al. Cell Chem Biol. 2024 Oct 17;31(10):1772-1786.e5. doi: 10.1016/j.chembiol.2024.09.001. Epub 2024 Sep 27. Cell Chem Biol. 2024. PMID: 39341205