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An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug.
Biomaterials. 2023 Mar;294:121985. doi: 10.1016/j.biomaterials.2022.121985. Epub 2023 Jan 3.
Biomaterials. 2023.
PMID: 36630826
Free PMC article.
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding.
Adriaenssens A, Broichhagen J, de Bray A, Ast J, Hasib A, Jones B, Tomas A, Burgos NF, Woodward O, Lewis J, O'Flaherty E, El K, Cui C, Harada N, Inagaki N, Campbell J, Brierley D, Hodson DJ, Samms R, Gribble F, Reimann F.
Adriaenssens A, et al.
JCI Insight. 2023 May 22;8(10):e164921. doi: 10.1172/jci.insight.164921.
JCI Insight. 2023.
PMID: 37212283
Free PMC article.
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Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.
Ozer I, Kelly G, Gu R, Li X, Zakharov N, Sirohi P, Nair SK, Collier JH, Hershfield MS, Hucknall AM, Chilkoti A.
Ozer I, et al.
Adv Sci (Weinh). 2022 Apr;9(11):e2103672. doi: 10.1002/advs.202103672. Epub 2022 Feb 8.
Adv Sci (Weinh). 2022.
PMID: 35133079
Free PMC article.
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