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An iron rheostat controls hematopoietic stem cell fate.
Kao YR, Chen J, Kumari R, Ng A, Zintiridou A, Tatiparthy M, Ma Y, Aivalioti MM, Moulik D, Sundaravel S, Sun D, Reisz JA, Grimm J, Martinez-Lopez N, Stransky S, Sidoli S, Steidl U, Singh R, D'Alessandro A, Will B. Kao YR, et al. Cell Stem Cell. 2024 Mar 7;31(3):378-397.e12. doi: 10.1016/j.stem.2024.01.011. Epub 2024 Feb 22. Cell Stem Cell. 2024. PMID: 38402617 Free article.
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging.
Mihaylova MM, Chaix A, Delibegovic M, Ramsey JJ, Bass J, Melkani G, Singh R, Chen Z, Ja WW, Shirasu-Hiza M, Latimer MN, Mattison JA, Thalacker-Mercer AE, Dixit VD, Panda S, Lamming DW. Mihaylova MM, et al. Cell Metab. 2023 Jul 11;35(7):1114-1131. doi: 10.1016/j.cmet.2023.06.008. Epub 2023 Jun 30. Cell Metab. 2023. PMID: 37392742 Free PMC article. Review.
mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission.
Martinez-Lopez N, Mattar P, Toledo M, Bains H, Kalyani M, Aoun ML, Sharma M, McIntire LBJ, Gunther-Cummins L, Macaluso FP, Aguilan JT, Sidoli S, Bourdenx M, Singh R. Martinez-Lopez N, et al. Nat Cell Biol. 2023 Jul;25(7):989-1003. doi: 10.1038/s41556-023-01163-3. Epub 2023 Jun 29. Nat Cell Biol. 2023. PMID: 37386153 Free PMC article.
Insulin and leptin oscillations license food-entrained browning and metabolic flexibility.
Mattar P, Reginato A, Lavados C, Das D, Kalyani M, Martinez-Lopez N, Sharma M, Skovbjerg G, Skytte JL, Roostalu U, Subbarayan R, Picarda E, Zang X, Zhang J, Guha C, Schwartz G, Rajbhandari P, Singh R. Mattar P, et al. Cell Rep. 2024 Jul 23;43(7):114390. doi: 10.1016/j.celrep.2024.114390. Epub 2024 Jun 19. Cell Rep. 2024. PMID: 38900636 Free PMC article.
VPS4A is the selective receptor for lipophagy in mice and humans.
Das D, Sharma M, Gahlot D, Nia SS, Gain C, Mecklenburg M, Zhou ZH, Bourdenx M, Thukral L, Martinez-Lopez N, Singh R. Das D, et al. Mol Cell. 2024 Nov 21;84(22):4436-4453.e8. doi: 10.1016/j.molcel.2024.10.022. Epub 2024 Nov 8. Mol Cell. 2024. PMID: 39520981 Free article.