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Page 1
Lactate regulates cell cycle by remodelling the anaphase promoting complex.
Liu W, Wang Y, Bozi LHM, Fischer PD, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao JJ, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET. Liu W, et al. Nature. 2023 Apr;616(7958):790-797. doi: 10.1038/s41586-023-05939-3. Epub 2023 Mar 15. Nature. 2023. PMID: 36921622
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET. Mills EL, et al. Nat Metab. 2021 May;3(5):604-617. doi: 10.1038/s42255-021-00389-5. Epub 2021 May 17. Nat Metab. 2021. PMID: 34002097 Free PMC article. Review.
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.
Xiao H, Jedrychowski MP, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li J, Long J, Mills EL, Szpyt J, He Z, Du G, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang T, Gray NS, Gygi SP, Chouchani ET. Xiao H, et al. Cell. 2020 Mar 5;180(5):968-983.e24. doi: 10.1016/j.cell.2020.02.012. Epub 2020 Feb 27. Cell. 2020. PMID: 32109415 Free PMC article.
Gasdermin D pore-forming activity is redox-sensitive.
Devant P, Boršić E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovič I, Evavold CL, Kagan JC. Devant P, et al. Cell Rep. 2023 Jan 31;42(1):112008. doi: 10.1016/j.celrep.2023.112008. Epub 2023 Jan 19. Cell Rep. 2023. PMID: 36662620 Free PMC article.
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Mills EL, et al. Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18. Nature. 2018. PMID: 30022159 Free PMC article.
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM. Sun Y, et al. Nature. 2021 May;593(7860):580-585. doi: 10.1038/s41586-021-03533-z. Epub 2021 May 12. Nature. 2021. PMID: 33981039 Free PMC article.
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.
Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM. Mittenbühler MJ, et al. Cell Metab. 2023 Mar 7;35(3):535-549.e7. doi: 10.1016/j.cmet.2022.12.014. Epub 2023 Jan 20. Cell Metab. 2023. PMID: 36681077 Free PMC article.
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics.
Campos JC, Marchesi Bozi LH, Krum B, Grassmann Bechara LR, Ferreira ND, Arini GS, Albuquerque RP, Traa A, Ogawa T, van der Bliek AM, Beheshti A, Chouchani ET, Van Raamsdonk JM, Blackwell TK, Ferreira JCB. Campos JC, et al. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2204750120. doi: 10.1073/pnas.2204750120. Epub 2023 Jan 3. Proc Natl Acad Sci U S A. 2023. PMID: 36595699 Free PMC article.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Mills EL, et al. Cell Metab. 2022 Jan 4;34(1):140-157.e8. doi: 10.1016/j.cmet.2021.11.003. Epub 2021 Dec 2. Cell Metab. 2022. PMID: 34861155 Free PMC article.
29 results