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Energetics, epigenetics, mitochondrial genetics.
Wallace DC, Fan W. Wallace DC, et al. Mitochondrion. 2010 Jan;10(1):12-31. doi: 10.1016/j.mito.2009.09.006. Epub 2009 Sep 29. Mitochondrion. 2010. PMID: 19796712 Free PMC article. Review.
A mitochondrial etiology of Alzheimer and Parkinson disease.
Coskun P, Wyrembak J, Schriner SE, Chen HW, Marciniack C, Laferla F, Wallace DC. Coskun P, et al. Biochim Biophys Acta. 2012 May;1820(5):553-64. doi: 10.1016/j.bbagen.2011.08.008. Epub 2011 Aug 16. Biochim Biophys Acta. 2012. PMID: 21871538 Free PMC article. Review.
Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS.
Desquiret-Dumas V, Gueguen N, Barth M, Chevrollier A, Hancock S, Wallace DC, Amati-Bonneau P, Henrion D, Bonneau D, Reynier P, Procaccio V. Desquiret-Dumas V, et al. Biochim Biophys Acta. 2012 Jun;1822(6):1019-29. doi: 10.1016/j.bbadis.2012.01.010. Epub 2012 Jan 28. Biochim Biophys Acta. 2012. PMID: 22306605 Free PMC article.