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Page 1
The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.
Sanchez JE, Noor S, Sun MS, Zimmerly J, Pasmay A, Sanchez JJ, Vanderwall AG, Haynes MK, Sklar LA, Escalona PR, Milligan ED. Sanchez JE, et al. Neurosci Lett. 2023 Sep 25;814:137419. doi: 10.1016/j.neulet.2023.137419. Epub 2023 Aug 7. Neurosci Lett. 2023. PMID: 37558176 Free PMC article.
Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG.
Wilkerson JL, Alberti LB, Thakur GA, Makriyannis A, Milligan ED. Wilkerson JL, et al. Brain Res. 2022 Jan 1;1774:147721. doi: 10.1016/j.brainres.2021.147721. Epub 2021 Nov 10. Brain Res. 2022. PMID: 34774500 Free PMC article.
Spinal interleukin-10 therapy to treat peripheral neuropathic pain.
Milligan ED, Penzkover KR, Soderquist RG, Mahoney MJ. Milligan ED, et al. Neuromodulation. 2012 Nov-Dec;15(6):520-6; discussion 526. doi: 10.1111/j.1525-1403.2012.00462.x. Epub 2012 Jun 1. Neuromodulation. 2012. PMID: 22672183 Free PMC article. Review.
Glia in pathological pain: a role for fractalkine.
Milligan ED, Sloane EM, Watkins LR. Milligan ED, et al. J Neuroimmunol. 2008 Jul 31;198(1-2):113-20. doi: 10.1016/j.jneuroim.2008.04.011. Epub 2008 Jun 10. J Neuroimmunol. 2008. PMID: 18547654 Free PMC article. Review.
30 results