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FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen IX, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain RK, Vander Heiden MG. Ferraro GB, et al. Nat Cancer. 2021 Apr;2(4):414-428. doi: 10.1038/s43018-021-00183-y. Epub 2021 Apr 1. Nat Cancer. 2021. PMID: 34179825 Free PMC article.
Cancer tissue of origin constrains the growth and metabolism of metastases.
Sivanand S, Gultekin Y, Winter PS, Vermeulen SY, Tchourine KM, Abbott KL, Danai LV, Gourgue F, Do BT, Crowder K, Kunchok T, Lau AN, Darnell AM, Jefferson A, Morita S, Duda DG, Aguirre AJ, Wolpin BM, Henning N, Spanoudaki V, Maiorino L, Irvine DJ, Yilmaz OH, Lewis CA, Vitkup D, Shalek AK, Vander Heiden MG. Sivanand S, et al. Nat Metab. 2024 Sep;6(9):1668-1681. doi: 10.1038/s42255-024-01105-9. Epub 2024 Aug 19. Nat Metab. 2024. PMID: 39160333
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD-1 Therapy.
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DG. Chen J, et al. Cancer Immunol Res. 2024 Apr 2;12(4):400-412. doi: 10.1158/2326-6066.CIR-23-0486. Cancer Immunol Res. 2024. PMID: 38260999 Free PMC article.
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Abbott KL, Ali A, Casalena D, Do BT, Ferreira R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, Renner S, Honeder SE, Wu M, Chan SH, Tseyang T, Stoltzfus AT, Michel SLJ, Greaves D, Hsu PP, Ng CW, Zhang CJ, Farsidjani A, Kent JR, Madariaga MLL, Gramatikov IMT, Matheson NJ, Lewis CA, Clish CB, Rees MG, Roth JA, Griner LM, Muir A, Auld DS, Vander Heiden MG. Abbott KL, et al. Cell Chem Biol. 2023 Sep 21;30(9):1156-1168.e7. doi: 10.1016/j.chembiol.2023.08.007. Epub 2023 Sep 8. Cell Chem Biol. 2023. PMID: 37689063 Free PMC article.
Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.
Iorgulescu JB, Ruthen N, Ahn R, Panagioti E, Gokhale PC, Neagu M, Speranza MC, Eschle BK, Soroko KM, Piranlioglu R, Datta M, Krishnan S, Yates KB, Baker GJ, Jain RK, Suvà ML, Neuberg D, White FM, Chiocca EA, Freeman GJ, Sharpe AH, Wu CJ, Reardon DA. Iorgulescu JB, et al. Front Immunol. 2023 Dec 28;14:1297932. doi: 10.3389/fimmu.2023.1297932. eCollection 2023. Front Immunol. 2023. PMID: 38213329 Free PMC article.
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG. Abbott KL, et al. Elife. 2024 May 24;13:RP95652. doi: 10.7554/eLife.95652. Elife. 2024. PMID: 38787918 Free PMC article.
Inhibiting GLUTtony in cancer.
Chang SM, Vander Heiden MG. Chang SM, et al. Cell Chem Biol. 2022 Mar 17;29(3):353-355. doi: 10.1016/j.chembiol.2022.03.004. Cell Chem Biol. 2022. PMID: 35303439 Free article.
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, Xu L, Barry CE 3rd, Jain RK. Datta M, et al. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2321336121. doi: 10.1073/pnas.2321336121. Epub 2024 Mar 26. Proc Natl Acad Sci U S A. 2024. PMID: 38530888 Free PMC article.
31 results