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Page 1
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.
Metabolism of immune cells in cancer.
Leone RD, Powell JD. Leone RD, et al. Nat Rev Cancer. 2020 Sep;20(9):516-531. doi: 10.1038/s41568-020-0273-y. Epub 2020 Jul 6. Nat Rev Cancer. 2020. PMID: 32632251 Free PMC article. Review.
Clinical development of metabolic inhibitors for oncology.
Lemberg KM, Gori SS, Tsukamoto T, Rais R, Slusher BS. Lemberg KM, et al. J Clin Invest. 2022 Jan 4;132(1):e148550. doi: 10.1172/JCI148550. J Clin Invest. 2022. PMID: 34981784 Free PMC article. Review.
GOT1 regulates CD8+ effector and memory T cell generation.
Xu W, Patel CH, Zhao L, Sun IH, Oh MH, Sun IM, Helms RS, Wen J, Powell JD. Xu W, et al. Cell Rep. 2023 Jan 31;42(1):111987. doi: 10.1016/j.celrep.2022.111987. Epub 2023 Jan 12. Cell Rep. 2023. PMID: 36640309 Free PMC article.
30 results