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Page 1
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L. Weiss-Sadan T, et al. Cell Metab. 2023 Mar 7;35(3):487-503.e7. doi: 10.1016/j.cmet.2023.01.012. Epub 2023 Feb 24. Cell Metab. 2023. PMID: 36841242 Free PMC article.
KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance.
Zavitsanou AM, Pillai R, Hao Y, Wu WL, Bartnicki E, Karakousi T, Rajalingam S, Herrera A, Karatza A, Rashidfarrokhi A, Solis S, Ciampricotti M, Yeaton AH, Ivanova E, Wohlhieter CA, Buus TB, Hayashi M, Karadal-Ferrena B, Pass HI, Poirier JT, Rudin CM, Wong KK, Moreira AL, Khanna KM, Tsirigos A, Papagiannakopoulos T, Koralov SB. Zavitsanou AM, et al. Cell Rep. 2023 Nov 28;42(11):113295. doi: 10.1016/j.celrep.2023.113295. Epub 2023 Oct 26. Cell Rep. 2023. PMID: 37889752 Free PMC article.
Valine tRNA levels and availability regulate complex I assembly in leukaemia.
Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Thandapani P, et al. Nature. 2022 Jan;601(7893):428-433. doi: 10.1038/s41586-021-04244-1. Epub 2021 Dec 22. Nature. 2022. PMID: 34937946 Free PMC article.
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T. Romero R, et al. Nat Med. 2017 Nov;23(11):1362-1368. doi: 10.1038/nm.4407. Epub 2017 Oct 2. Nat Med. 2017. PMID: 28967920 Free PMC article.
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.
Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T. Pillai R, et al. Sci Adv. 2024 Mar 29;10(13):eadm9859. doi: 10.1126/sciadv.adm9859. Epub 2024 Mar 27. Sci Adv. 2024. PMID: 38536921 Free PMC article.
NRF2: KEAPing Tumors Protected.
Pillai R, Hayashi M, Zavitsanou AM, Papagiannakopoulos T. Pillai R, et al. Cancer Discov. 2022 Mar 1;12(3):625-643. doi: 10.1158/2159-8290.CD-21-0922. Cancer Discov. 2022. PMID: 35101864 Free PMC article.
Metabolic features of cancer cells in NRF2 addiction status.
Okazaki K, Papagiannakopoulos T, Motohashi H. Okazaki K, et al. Biophys Rev. 2020 Apr;12(2):435-441. doi: 10.1007/s12551-020-00659-8. Epub 2020 Feb 28. Biophys Rev. 2020. PMID: 32112372 Free PMC article. Review.
14 results