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The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links.
Altshuller M, He X, MacKrell EJ, Wernke KM, Wong JWH, Sellés-Baiget S, Wang TY, Chou TF, Duxin JP, Balskus EP, Herzon SB, Semlow DR. Altshuller M, et al. bioRxiv [Preprint]. 2024 Jan 31:2024.01.30.576698. doi: 10.1101/2024.01.30.576698. bioRxiv. 2024. PMID: 38352618 Free PMC article. Preprint.
Natural product discovery from the human microbiome.
Wilson MR, Zha L, Balskus EP. Wilson MR, et al. J Biol Chem. 2017 May 26;292(21):8546-8552. doi: 10.1074/jbc.R116.762906. Epub 2017 Apr 7. J Biol Chem. 2017. PMID: 28389564 Free PMC article. Review.
A small molecule inhibitor prevents gut bacterial genotoxin production.
Volpe MR, Velilla JA, Daniel-Ivad M, Yao JJ, Stornetta A, Villalta PW, Huang HC, Bachovchin DA, Balbo S, Gaudet R, Balskus EP. Volpe MR, et al. Nat Chem Biol. 2023 Feb;19(2):159-167. doi: 10.1038/s41589-022-01147-8. Epub 2022 Oct 17. Nat Chem Biol. 2023. PMID: 36253549 Free PMC article.
The human gut bacterial genotoxin colibactin alkylates DNA.
Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP. Wilson MR, et al. Science. 2019 Feb 15;363(6428):eaar7785. doi: 10.1126/science.aar7785. Science. 2019. PMID: 30765538 Free PMC article.
Structural basis of colibactin activation by the ClbP peptidase.
Velilla JA, Volpe MR, Kenney GE, Walsh RM Jr, Balskus EP, Gaudet R. Velilla JA, et al. Nat Chem Biol. 2023 Feb;19(2):151-158. doi: 10.1038/s41589-022-01142-z. Epub 2022 Oct 17. Nat Chem Biol. 2023. PMID: 36253550 Free PMC article.
11 results