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Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome.
Marzese DM, Liu M, Huynh JL, Hirose H, Donovan NC, Huynh KT, Kiyohara E, Chong K, Cheng D, Tanaka R, Wang J, Morton DL, Barkhoudarian G, Kelly DF, Hoon DS. Marzese DM, et al. Pigment Cell Melanoma Res. 2015 Jan;28(1):82-93. doi: 10.1111/pcmr.12307. Epub 2014 Sep 30. Pigment Cell Melanoma Res. 2015. PMID: 25169209 Free PMC article.
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