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Targeting DNA methylation.
Issa JP, Kantarjian HM. Issa JP, et al. Clin Cancer Res. 2009 Jun 15;15(12):3938-46. doi: 10.1158/1078-0432.CCR-08-2783. Epub 2009 Jun 9. Clin Cancer Res. 2009. PMID: 19509174 Free PMC article.
Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.
Figueiredo JC, Grau MV, Wallace K, Levine AJ, Shen L, Hamdan R, Chen X, Bresalier RS, McKeown-Eyssen G, Haile RW, Baron JA, Issa JP. Figueiredo JC, et al. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1041-9. doi: 10.1158/1055-9965.EPI-08-0926. Epub 2009 Mar 31. Cancer Epidemiol Biomarkers Prev. 2009. PMID: 19336559 Free PMC article. Clinical Trial.