R01 AI157046/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	1
2020	7
2021	12
2022	16
2023	3
2024	1
2025	0

1

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

2

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.

Tan H, Hu Y, Jadhav P, Tan B, Wang J. Tan H, et al. J Med Chem. 2022 Jun 9;65(11):7561-7580. doi: 10.1021/acs.jmedchem.2c00303. Epub 2022 May 27. J Med Chem. 2022. PMID: 35620927 Free PMC article. Review.

3

Enterovirus D68 Antivirals: Past, Present, and Future.

Hu Y, Musharrafieh R, Zheng M, Wang J. Hu Y, et al. ACS Infect Dis. 2020 Jul 10;6(7):1572-1586. doi: 10.1021/acsinfecdis.0c00120. Epub 2020 May 14. ACS Infect Dis. 2020. PMID: 32352280 Free PMC article. Review.

4

Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.

Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J. Tan B, et al. J Med Chem. 2023 Nov 9;66(21):14544-14563. doi: 10.1021/acs.jmedchem.3c00995. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857371 Free PMC article.

5

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors.

Ma C, Wang J. Ma C, et al. ACS Pharmacol Transl Sci. 2022 Jan 24;5(2):102-109. doi: 10.1021/acsptsci.1c00240. eCollection 2022 Feb 11. ACS Pharmacol Transl Sci. 2022. PMID: 35178512 Free PMC article.

6

The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations.

Joyce RP, Hu VW, Wang J. Joyce RP, et al. Med Chem Res. 2022;31(10):1637-1646. doi: 10.1007/s00044-022-02951-6. Epub 2022 Aug 30. Med Chem Res. 2022. PMID: 36060104 Free PMC article. Review.

7

Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor.

Ma C, Hu Y, Wang Y, Choza J, Wang J. Ma C, et al. ACS Infect Dis. 2022 May 13;8(5):1022-1030. doi: 10.1021/acsinfecdis.1c00629. Epub 2022 Apr 11. ACS Infect Dis. 2022. PMID: 35404564 Free PMC article.

8

Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays.

Ma C, Tan H, Choza J, Wang Y, Wang J. Ma C, et al. Acta Pharm Sin B. 2022 Apr;12(4):1636-1651. doi: 10.1016/j.apsb.2021.10.026. Epub 2021 Nov 1. Acta Pharm Sin B. 2022. PMID: 34745850 Free PMC article.

9

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.

Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, Chen Y, Wang J. Kitamura N, et al. J Med Chem. 2022 Feb 24;65(4):2848-2865. doi: 10.1021/acs.jmedchem.1c00509. Epub 2021 Apr 23. J Med Chem. 2022. PMID: 33891389 Free PMC article.

10

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.

Hu Y, Lewandowski EM, Tan H, Zhang X, Morgan RT, Zhang X, Jacobs LMC, Butler SG, Gongora MV, Choy J, Deng X, Chen Y, Wang J. Hu Y, et al. bioRxiv [Preprint]. 2022 Sep 6:2022.06.28.497978. doi: 10.1101/2022.06.28.497978. bioRxiv. 2022. Update in: ACS Cent Sci. 2023 Jul 24;9(8):1658-1669. doi: 10.1021/acscentsci.3c00538 PMID: 36119652 Free PMC article. Updated. Preprint.

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