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Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, Reja R, Cheung TK, Liang Y, Webster JD, Lehoux I, Skippington E, Reeder J, Haley B, Tan MW, Rose CM, Newton K, Kayagaki N, Vance RE, Dixit VM. Luchetti G, et al. Cell Host Microbe. 2021 Oct 13;29(10):1521-1530.e10. doi: 10.1016/j.chom.2021.08.010. Epub 2021 Sep 6. Cell Host Microbe. 2021. PMID: 34492225 Free PMC article.
NAIP-NLRC4-deficient mice are susceptible to shigellosis.
Mitchell PS, Roncaioli JL, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance RE. Mitchell PS, et al. Elife. 2020 Oct 19;9:e59022. doi: 10.7554/eLife.59022. Elife. 2020. PMID: 33074100 Free PMC article.
Fungal gasdermin-like proteins are controlled by proteolytic cleavage.
Clavé C, Dyrka W, Turcotte EA, Granger-Farbos A, Ibarlosa L, Pinson B, Vance RE, Saupe SJ, Daskalov A. Clavé C, et al. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2109418119. doi: 10.1073/pnas.2109418119. Proc Natl Acad Sci U S A. 2022. PMID: 35135876 Free PMC article.
Molecular characterization of a fungal gasdermin-like protein.
Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NL. Daskalov A, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18600-18607. doi: 10.1073/pnas.2004876117. Epub 2020 Jul 23. Proc Natl Acad Sci U S A. 2020. PMID: 32703806 Free PMC article.
11 results