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Page 1
Senolytics reduce coronavirus-related mortality in old mice.
Camell CD, Yousefzadeh MJ, Zhu Y, Prata LGPL, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Espindola-Netto JM, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Camell CD, et al. Science. 2021 Jul 16;373(6552):eabe4832. doi: 10.1126/science.abe4832. Epub 2021 Jun 8. Science. 2021. PMID: 34103349 Free PMC article.
Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. Beura LK, et al. Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20. Nature. 2016. PMID: 27096360 Free PMC article.
Embracing microbial exposure in mouse research.
Huggins MA, Jameson SC, Hamilton SE. Huggins MA, et al. J Leukoc Biol. 2019 Jan;105(1):73-79. doi: 10.1002/JLB.4RI0718-273R. Epub 2018 Sep 27. J Leukoc Biol. 2019. PMID: 30260516 Free PMC article. Review.
Mice with diverse microbial exposure histories as a model for preclinical vaccine testing.
Fiege JK, Block KE, Pierson MJ, Nanda H, Shepherd FK, Mickelson CK, Stolley JM, Matchett WE, Wijeyesinghe S, Meyerholz DK, Vezys V, Shen SS, Hamilton SE, Masopust D, Langlois RA. Fiege JK, et al. Cell Host Microbe. 2021 Dec 8;29(12):1815-1827.e6. doi: 10.1016/j.chom.2021.10.001. Epub 2021 Nov 2. Cell Host Microbe. 2021. PMID: 34731647 Free PMC article.
New Insights into the Immune System Using Dirty Mice.
Hamilton SE, Badovinac VP, Beura LK, Pierson M, Jameson SC, Masopust D, Griffith TS. Hamilton SE, et al. J Immunol. 2020 Jul 1;205(1):3-11. doi: 10.4049/jimmunol.2000171. J Immunol. 2020. PMID: 32571979 Free PMC article. Review.
Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
Huggins MA, Sjaastad FV, Pierson M, Kucaba TA, Swanson W, Staley C, Weingarden AR, Jensen IJ, Danahy DB, Badovinac VP, Jameson SC, Vezys V, Masopust D, Khoruts A, Griffith TS, Hamilton SE. Huggins MA, et al. Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028. Cell Rep. 2019. PMID: 31412243 Free PMC article.