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Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.
Zimmerman O, Zimmerman MI, Raju S, Nelson CA, Errico JM, Madden EA, Holmes AC, Hassan AO, VanBlargan LA, Kim AS, Adams LJ, Basore K, Whitener BM, Palakurty S, Davis-Adams HG, Sun C, Gilliland T Jr, Earnest JT, Ma H, Ebel GD, Zmasek C, Scheuermann RH, Klimstra WB, Fremont DH, Diamond MS. Zimmerman O, et al. Cell. 2023 Oct 26;186(22):4818-4833.e25. doi: 10.1016/j.cell.2023.09.007. Epub 2023 Oct 6. Cell. 2023. PMID: 37804831 Free PMC article.
Mxra8 is a receptor for multiple arthritogenic alphaviruses.
Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Zhang R, et al. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. Nature. 2018. PMID: 29769725 Free PMC article.
A molecular understanding of alphavirus entry.
Holmes AC, Basore K, Fremont DH, Diamond MS. Holmes AC, et al. PLoS Pathog. 2020 Oct 22;16(10):e1008876. doi: 10.1371/journal.ppat.1008876. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33091085 Free PMC article. Review.
Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
Powell LA, Miller A, Fox JM, Kose N, Klose T, Kim AS, Bombardi R, Tennekoon RN, Dharshan de Silva A, Carnahan RH, Diamond MS, Rossmann MG, Kuhn RJ, Crowe JE Jr. Powell LA, et al. Cell Host Microbe. 2020 Nov 11;28(5):699-711.e7. doi: 10.1016/j.chom.2020.07.008. Epub 2020 Aug 11. Cell Host Microbe. 2020. PMID: 32783883 Free PMC article.
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH. Basore K, et al. Cell. 2019 Jun 13;177(7):1725-1737.e16. doi: 10.1016/j.cell.2019.04.006. Epub 2019 May 9. Cell. 2019. PMID: 31080061 Free PMC article.
31 results