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Adjuvants influence the maturation of VRC01-like antibodies during immunization.
Knudsen ML, Agrawal P, MacCamy A, Parks KR, Gray MD, Takushi BN, Khechaduri A, Salladay KR, Coler RN, LaBranche CC, Montefiori D, Stamatatos L. Knudsen ML, et al. iScience. 2022 Nov 2;25(11):105473. doi: 10.1016/j.isci.2022.105473. eCollection 2022 Nov 18. iScience. 2022. PMID: 36405776 Free PMC article.
HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.
LaBranche CC, McGuire AT, Gray MD, Behrens S, Kwong PDK, Chen X, Zhou T, Sattentau QJ, Peacock J, Eaton A, Greene K, Gao H, Tang H, Perez LG, Chen X, Saunders KO, Kwong PD, Mascola JR, Haynes BF, Stamatatos L, Montefiori DC. LaBranche CC, et al. PLoS Pathog. 2018 Nov 5;14(11):e1007431. doi: 10.1371/journal.ppat.1007431. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30395637 Free PMC article.
A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component.
Bricault CA, Kovacs JM, Nkolola JP, Yusim K, Giorgi EE, Shields JL, Perry J, Lavine CL, Cheung A, Ellingson-Strouss K, Rademeyer C, Gray GE, Williamson C, Stamatatos L, Seaman MS, Korber BT, Chen B, Barouch DH. Bricault CA, et al. J Virol. 2015 Mar;89(5):2507-19. doi: 10.1128/JVI.03331-14. Epub 2014 Dec 24. J Virol. 2015. PMID: 25540368 Free PMC article.
Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.
Parks KR, MacCamy AJ, Trichka J, Gray M, Weidle C, Borst AJ, Khechaduri A, Takushi B, Agrawal P, Guenaga J, Wyatt RT, Coler R, Seaman M, LaBranche C, Montefiori DC, Veesler D, Pancera M, McGuire A, Stamatatos L. Parks KR, et al. Cell Rep. 2019 Dec 3;29(10):3060-3072.e7. doi: 10.1016/j.celrep.2019.10.071. Cell Rep. 2019. PMID: 31801073 Free PMC article.
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env.
Agrawal P, Knudsen ML, MacCamy A, Hurlburt NK, Khechaduri A, Salladay KR, Kher GM, Kallur Siddaramaiah L, Stuart AB, Bontjer I, Shen X, Montefiori D, Gristick HB, Bjorkman PJ, Sanders RW, Pancera M, Stamatatos L. Agrawal P, et al. J Virol. 2024 Oct 22;98(10):e0074424. doi: 10.1128/jvi.00744-24. Epub 2024 Sep 6. J Virol. 2024. PMID: 39240111 Free PMC article.
13 results