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Page 1
Covalent inhibition of pro-apoptotic BAX.
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. McHenry MW, et al. Nat Chem Biol. 2024 Aug;20(8):1022-1032. doi: 10.1038/s41589-023-01537-6. Epub 2024 Jan 17. Nat Chem Biol. 2024. PMID: 38233584
Two-state selection of conformation-specific antibodies.
Gao J, Sidhu SS, Wells JA. Gao J, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3071-6. doi: 10.1073/pnas.0812952106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208804 Free PMC article.
An allosteric circuit in caspase-1.
Datta D, Scheer JM, Romanowski MJ, Wells JA. Datta D, et al. J Mol Biol. 2008 Sep 19;381(5):1157-67. doi: 10.1016/j.jmb.2008.06.040. Epub 2008 Jun 20. J Mol Biol. 2008. PMID: 18590738 Free PMC article.
Inflammatory stimuli regulate caspase substrate profiles.
Agard NJ, Maltby D, Wells JA. Agard NJ, et al. Mol Cell Proteomics. 2010 May;9(5):880-93. doi: 10.1074/mcp.M900528-MCP200. Epub 2010 Feb 20. Mol Cell Proteomics. 2010. PMID: 20173201 Free PMC article.
Ordering a dynamic protein via a small-molecule stabilizer.
Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL 3rd, Wells JA, Mapp AK. Wang N, et al. J Am Chem Soc. 2013 Mar 6;135(9):3363-6. doi: 10.1021/ja3122334. Epub 2013 Feb 22. J Am Chem Soc. 2013. PMID: 23384013 Free PMC article.