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Page 1
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.
Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, Reiman EM, Haroutunian V, Wang M, Schadt E, Zhang B, Dickson DW, Ertekin-Taner N, Golde TE, Petyuk VA, De Jager PL, Bennett DA, Wingo TS, Rangaraju S, Hajjar I, Shulman JM, Lah JJ, Levey AI, Seyfried NT. Johnson ECB, et al. Nat Med. 2020 May;26(5):769-780. doi: 10.1038/s41591-020-0815-6. Epub 2020 Apr 13. Nat Med. 2020. PMID: 32284590 Free PMC article.
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai B, Wang X, Li Y, Chen PC, Yu K, Dey KK, Yarbro JM, Han X, Lutz BM, Rao S, Jiao Y, Sifford JM, Han J, Wang M, Tan H, Shaw TI, Cho JH, Zhou S, Wang H, Niu M, Mancieri A, Messler KA, Sun X, Wu Z, Pagala V, High AA, Bi W, Zhang H, Chi H, Haroutunian V, Zhang B, Beach TG, Yu G, Peng J. Bai B, et al. Neuron. 2020 Mar 18;105(6):975-991.e7. doi: 10.1016/j.neuron.2019.12.015. Epub 2020 Jan 8. Neuron. 2020. PMID: 31926610 Free PMC article.
Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease.
Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, Kastenmüller G, Han X, Baillie R, Zeng Q, Andrews S, Cheng H, Hao K, Goate A, Bennett DA, Saykin AJ, Kaddurah-Daouk R, Zhang B; Alzheimer's Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Metabolomics Consortium. Horgusluoglu E, et al. Alzheimers Dement. 2022 Jun;18(6):1260-1278. doi: 10.1002/alz.12468. Epub 2021 Nov 10. Alzheimers Dement. 2022. PMID: 34757660 Free PMC article.
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L. Sayed FA, et al. Sci Transl Med. 2021 Dec;13(622):eabe3947. doi: 10.1126/scitranslmed.abe3947. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851693 Free PMC article.
55 results