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Page 1
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. Chini CCS, et al. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199925 Free PMC article.
p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. Sturmlechner I, et al. Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29. Science. 2021. PMID: 34709885 Free PMC article.
Senescent cells in the development of cardiometabolic disease.
Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK. Postmus AC, et al. Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602. Curr Opin Lipidol. 2019. PMID: 30913069 Free PMC article. Review.
Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.
Cherry C, Andorko JI, Krishnan K, Mejías JC, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Peña AN, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JH. Cherry C, et al. Geroscience. 2023 Aug;45(4):2559-2587. doi: 10.1007/s11357-023-00785-7. Epub 2023 Apr 20. Geroscience. 2023. PMID: 37079217 Free PMC article.
Senolytic therapies for healthy longevity.
van Deursen JM. van Deursen JM. Science. 2019 May 17;364(6441):636-637. doi: 10.1126/science.aaw1299. Science. 2019. PMID: 31097655 Free PMC article. No abstract available.
Therapy-Induced Senescence Drives Bone Loss.
Yao Z, Murali B, Ren Q, Luo X, Faget DV, Cole T, Ricci B, Thotala D, Monahan J, van Deursen JM, Baker D, Faccio R, Schwarz JK, Stewart SA. Yao Z, et al. Cancer Res. 2020 Mar 1;80(5):1171-1182. doi: 10.1158/0008-5472.CAN-19-2348. Epub 2020 Jan 13. Cancer Res. 2020. PMID: 31932453 Free PMC article.