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β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents.
Gereau GB, Zhou D, Van Voorhies K, Tyler RE, Campbell J, Murray JG, Alvarez-Pamir A, Wykoff LA, Companion MA, Jackson MR, Olson SH, Barak LS, Slosky LM, Vetreno RP, Besheer J, McElligott ZA. Gereau GB, et al. bioRxiv [Preprint]. 2024 Apr 13:2024.04.10.588903. doi: 10.1101/2024.04.10.588903. bioRxiv. 2024. PMID: 38645173 Free PMC article. Preprint.
Design of allosteric modulators that change GPCR G protein subtype selectivity.
Moore MN, Person KL, Alwin A, Krusemark C, Foster N, Ray C, Inoue A, Jackson MR, Sheedlo MJ, Barak LS, Fernandez de Velasco EM, Olson SH, Slosky LM. Moore MN, et al. bioRxiv [Preprint]. 2024 Nov 21:2024.11.20.624209. doi: 10.1101/2024.11.20.624209. bioRxiv. 2024. PMID: 39605353 Free PMC article. Preprint.
Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine.
Gross JD, Kim DW, Zhou Y, Jansen D, Slosky LM, Clark NB, Ray CR, Hu X, Southall N, Wang A, Xu X, Barnaeva E, Wetsel WC, Ferrer M, Marugan JJ, Caron MG, Barak LS, Toth K. Gross JD, et al. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2112397119. doi: 10.1073/pnas.2112397119. Epub 2022 Mar 3. Proc Natl Acad Sci U S A. 2022. PMID: 35239443 Free PMC article.
Design of allosteric modulators that change GPCR G protein subtype selectivity.
Moore MN, Person KL, Alwin A, Krusemark C, Foster N, Ray C, Inoue A, Jackson MR, Sheedlo MJ, Barak LS, de Velasco EMF, Olson SH, Slosky LM. Moore MN, et al. Res Sq [Preprint]. 2024 Dec 11:rs.3.rs-5538058. doi: 10.21203/rs.3.rs-5538058/v1. Res Sq. 2024. PMID: 39711540 Free PMC article. Preprint.