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98 results

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Page 1
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.
Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM. Bosch B, et al. Cell. 2021 Aug 19;184(17):4579-4592.e24. doi: 10.1016/j.cell.2021.06.033. Epub 2021 Jul 22. Cell. 2021. PMID: 34297925 Free PMC article.
A robust pipeline for rapid production of versatile nanobody repertoires.
Fridy PC, Li Y, Keegan S, Thompson MK, Nudelman I, Scheid JF, Oeffinger M, Nussenzweig MC, Fenyö D, Chait BT, Rout MP. Fridy PC, et al. Nat Methods. 2014 Dec;11(12):1253-60. doi: 10.1038/nmeth.3170. Epub 2014 Nov 2. Nat Methods. 2014. PMID: 25362362 Free PMC article.
Touching from a distance.
Holden JM, Koreny L, Kelly S, Chait BT, Rout MP, Field MC, Obado SO. Holden JM, et al. Nucleus. 2014 Jul-Aug;5(4):304-10. doi: 10.4161/nucl.32228. Nucleus. 2014. PMID: 25482119 Free PMC article.
Structural basis for substrate selection by the SARS-CoV-2 replicase.
Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Götte M, Chait BT, Campbell EA, Darst SA. Malone BF, et al. Nature. 2023 Feb;614(7949):781-787. doi: 10.1038/s41586-022-05664-3. Epub 2023 Feb 1. Nature. 2023. PMID: 36725929 Free PMC article.
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22. J Am Chem Soc. 2024. PMID: 38134034
Shelterin is a dimeric complex with extensive structural heterogeneity.
Zinder JC, Olinares PDB, Svetlov V, Bush MW, Nudler E, Chait BT, Walz T, de Lange T. Zinder JC, et al. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2201662119. doi: 10.1073/pnas.2201662119. Epub 2022 Jul 26. Proc Natl Acad Sci U S A. 2022. PMID: 35881804 Free PMC article.
Immunodominant surface epitopes power immune evasion in the African trypanosome.
Gkeka A, Aresta-Branco F, Triller G, Vlachou EP, van Straaten M, Lilic M, Olinares PDB, Perez K, Chait BT, Blatnik R, Ruppert T, Verdi JP, Stebbins CE, Papavasiliou FN. Gkeka A, et al. Cell Rep. 2023 Mar 28;42(3):112262. doi: 10.1016/j.celrep.2023.112262. Epub 2023 Mar 20. Cell Rep. 2023. PMID: 36943866 Free article.
98 results