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2021 7
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Page 1
Mitochondrial DNA Release in Innate Immune Signaling.
Newman LE, Shadel GS. Newman LE, et al. Annu Rev Biochem. 2023 Jun 20;92:299-332. doi: 10.1146/annurev-biochem-032620-104401. Epub 2023 Mar 31. Annu Rev Biochem. 2023. PMID: 37001140 Free PMC article. Review.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.
Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Malik N, et al. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. Science. 2023. PMID: 37079666 Free PMC article.
Manipulating mitochondrial electron flow enhances tumor immunogenicity.
Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Mangalhara KC, et al. Science. 2023 Sep 22;381(6664):1316-1323. doi: 10.1126/science.abq1053. Epub 2023 Sep 21. Science. 2023. PMID: 37733872 Free PMC article.
Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis.
Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J. Nassour J, et al. Nature. 2023 Feb;614(7949):767-773. doi: 10.1038/s41586-023-05710-8. Epub 2023 Feb 8. Nature. 2023. PMID: 36755096 Free PMC article.
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.
Wang B, Wang L, Gasek NS, Kuo CL, Nie J, Kim T, Yan P, Zhu J, Torrance BL, Zhou Y, Flores LC, Allen C, Andrade AM, Guo C, Cohn RL, Jellison ER, Bartley JM, Kuchel GA, Li S, Pirtskhalava T, Tchkonia T, Yadav S, Haynes L, Kirkland JL, Ikeno Y, Xu M. Wang B, et al. Cell Metab. 2024 Aug 6;36(8):1795-1805.e6. doi: 10.1016/j.cmet.2024.07.006. Cell Metab. 2024. PMID: 39111286
Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain.
Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, Saxena MD, Coorapati S, Parylak SL, Quintero C, Molina E, Andrade LR, Manor U, Gage FH. Wang M, et al. Nat Biotechnol. 2024 Feb 28:10.1038/s41587-024-02157-8. doi: 10.1038/s41587-024-02157-8. Online ahead of print. Nat Biotechnol. 2024. PMID: 38418648
STAT3 modulates CD4+ T mitochondrial dynamics and function in aging.
Zukowski E, Sannella M, Rockhold JD, Kalantar GH, Yu J, SantaCruz-Calvo S, Kuhn MK, Hah N, Ouyang L, Wang TW, Murphy L, Marszalkowski H, Gibney K, Drummond MJ, Proctor EA, Hasturk H, Nikolajczyk BS, Bharath LP. Zukowski E, et al. Aging Cell. 2023 Nov;22(11):e13996. doi: 10.1111/acel.13996. Epub 2023 Oct 13. Aging Cell. 2023. PMID: 37837188 Free PMC article.
39 results