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Page 1
Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin.
Kamath SD, Scheiblhofer S, Johnson CM, Machado Y, McLean T, Taki AC, Ramsland PA, Iyer S, Joubert I, Hofer H, Wallner M, Thalhamer J, Rolland J, O'Hehir R, Briza P, Ferreira F, Weiss R, Lopata AL. Kamath SD, et al. Allergy. 2020 Nov;75(11):2909-2919. doi: 10.1111/all.14410. Epub 2020 Jun 18. Allergy. 2020. PMID: 32436591 Free PMC article.
In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization.
Winter P, Stubenvoll S, Scheiblhofer S, Joubert IA, Strasser L, Briganser C, Soh WT, Hofer F, Kamenik AS, Dietrich V, Michelini S, Laimer J, Lackner P, Horejs-Hoeck J, Tollinger M, Liedl KR, Brandstetter J, Huber CG, Weiss R. Winter P, et al. Front Immunol. 2020 Aug 18;11:1824. doi: 10.3389/fimmu.2020.01824. eCollection 2020. Front Immunol. 2020. PMID: 33013833 Free PMC article.
Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.
Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. Machado Y, et al. J Allergy Clin Immunol. 2016 May;137(5):1525-34. doi: 10.1016/j.jaci.2015.09.026. Epub 2015 Nov 11. J Allergy Clin Immunol. 2016. PMID: 26559323 Free PMC article.
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