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A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro.
FEBS Lett. 2020 Feb;594(3):424-438. doi: 10.1002/1873-3468.13636. Epub 2019 Oct 30.
FEBS Lett. 2020.
PMID: 31605637
Free PMC article.
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.).
Lienhart WD, Gudipati V, Uhl MK, Binter A, Pulido SA, Saf R, Zangger K, Gruber K, Macheroux P.
Lienhart WD, et al.
FEBS J. 2014 Oct;281(20):4691-4704. doi: 10.1111/febs.12975. Epub 2014 Sep 19.
FEBS J. 2014.
PMID: 25143260
Free PMC article.
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