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Page 1
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.
Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Zaman K, et al. J Neurosci. 1999 Nov 15;19(22):9821-30. doi: 10.1523/JNEUROSCI.19-22-09821.1999. J Neurosci. 1999. PMID: 10559391 Free PMC article.
In vitro model of oxidative stress in cortical neurons.
Ratan RR, Ryu H, Lee J, Mwidau A, Neve RL. Ratan RR, et al. Methods Enzymol. 2002;352:183-90. doi: 10.1016/s0076-6879(02)52018-8. Methods Enzymol. 2002. PMID: 12125346 No abstract available.
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.
Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR. Haskew-Layton RE, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90. doi: 10.1073/pnas.1003996107. Epub 2010 Sep 20. Proc Natl Acad Sci U S A. 2010. PMID: 20855618 Free PMC article.