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Lymphocytes from mice chronically infected with Theiler's murine encephalomyelitis virus produce demyelination of organotypic cultures after stimulation with the major encephalitogenic epitope of myelin proteolipid protein. Epitope spreading in TMEV infection has functional activity.
Dal Canto MC, Calenoff MA, Miller SD, Vanderlugt CL. Dal Canto MC, et al. J Neuroimmunol. 2000 Apr 3;104(1):79-84. doi: 10.1016/s0165-5728(99)00230-1. J Neuroimmunol. 2000. PMID: 10683517