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Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion.
McNeel DG, Eickhoff J, Lee FT, King DM, Alberti D, Thomas JP, Friedl A, Kolesar J, Marnocha R, Volkman J, Zhang J, Hammershaimb L, Zwiebel JA, Wilding G. McNeel DG, et al. Clin Cancer Res. 2005 Nov 1;11(21):7851-60. doi: 10.1158/1078-0432.CCR-05-0262. Clin Cancer Res. 2005. PMID: 16278408 Clinical Trial.