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Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.
Santra S, Liao HX, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A, Quinn D, Parks RJ, Tsao CY, Carville A, Mansfield KG, Pavlakis GN, Felber BK, Haynes BF, Korber BT, Letvin NL. Santra S, et al. Nat Med. 2010 Mar;16(3):324-8. doi: 10.1038/nm.2108. Epub 2010 Feb 21. Nat Med. 2010. PMID: 20173754 Free PMC article.
Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques.
Luckay A, Sidhu MK, Kjeken R, Megati S, Chong SY, Roopchand V, Garcia-Hand D, Abdullah R, Braun R, Montefiori DC, Rosati M, Felber BK, Pavlakis GN, Mathiesen I, Israel ZR, Eldridge JH, Egan MA. Luckay A, et al. J Virol. 2007 May;81(10):5257-69. doi: 10.1128/JVI.00055-07. Epub 2007 Feb 28. J Virol. 2007. PMID: 17329330 Free PMC article.
Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.
Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, Waldmann TA, Eldridge J, Weiner DB. Boyer JD, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18648-53. doi: 10.1073/pnas.0709198104. Epub 2007 Nov 13. Proc Natl Acad Sci U S A. 2007. PMID: 18000037 Free PMC article.