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A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion.
Montaner M, Denom J, Simon V, Jiang W, Holt MK, Brierley DI, Rouch C, Foppen E, Kassis N, Jarriault D, Khan D, Eygret L, Mifsud F, Hodson DJ, Broichhagen J, Van Oudenhove L, Fioramonti X, Gault V, Cota D, Reimann F, Gribble FM, Migrenne-Li S, Trapp S, Gurden H, Magnan C. Montaner M, et al. Nat Commun. 2024 Aug 13;15(1):6941. doi: 10.1038/s41467-024-51076-4. Nat Commun. 2024. PMID: 39138162 Free PMC article.
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation.
Costa A, Ai M, Nunn N, Culotta I, Hunter J, Boudjadja MB, Valencia-Torres L, Aviello G, Hodson DJ, Snider BM, Coskun T, Emmerson PJ, Luckman SM, D'Agostino G. Costa A, et al. Mol Metab. 2022 Jan;55:101407. doi: 10.1016/j.molmet.2021.101407. Epub 2021 Nov 26. Mol Metab. 2022. PMID: 34844019 Free PMC article.
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation.
Cahill KN, Amin T, Boutaud O, Printz R, Newcomb DC, Foer D, Hodson DJ, Broichhagen J, Beckman JA, Yu C, Nian H, Mashayekhi M, Silver HJ, Luther JM, Brown NJ, Peebles RS Jr, Niswender K. Cahill KN, et al. JACC Basic Transl Sci. 2022 Jul 25;7(7):713-715. doi: 10.1016/j.jacbts.2022.04.004. eCollection 2022 Jul. JACC Basic Transl Sci. 2022. PMID: 35958685 Free PMC article. No abstract available.
72 results