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TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K. Woznicki JA, et al. Cell Death Dis. 2021 Sep 23;12(10):864. doi: 10.1038/s41419-021-04151-3. Cell Death Dis. 2021. PMID: 34556638 Free PMC article.
Therapeutics Targeting the Core Apoptotic Machinery.
Hamilton C, Fox JP, Longley DB, Higgins CA. Hamilton C, et al. Cancers (Basel). 2021 May 26;13(11):2618. doi: 10.3390/cancers13112618. Cancers (Basel). 2021. PMID: 34073507 Free PMC article. Review.
Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.
Flanagan DJ, Amirkhah R, Vincent DF, Gunduz N, Gentaz P, Cammareri P, McCooey AJ, McCorry AMB, Fisher NC, Davis HL, Ridgway RA, Lohuis J, Leach JDG, Jackstadt R, Gilroy K, Mariella E, Nixon C, Clark W, Hedley A, Markert EK, Strathdee D, Bartholin L, Redmond KL, Kerr EM, Longley DB, Ginty F, Cho S, Coleman HG, Loughrey MB, Bardelli A, Maughan TS, Campbell AD, Lawler M, Leedham SJ, Barry ST, Inman GJ, van Rheenen J, Dunne PD, Sansom OJ. Flanagan DJ, et al. Nat Commun. 2022 Dec 7;13(1):7551. doi: 10.1038/s41467-022-35134-3. Nat Commun. 2022. PMID: 36477656 Free PMC article.
The role of Ubiquitination in Apoptosis and Necroptosis.
Roberts JZ, Crawford N, Longley DB. Roberts JZ, et al. Cell Death Differ. 2022 Feb;29(2):272-284. doi: 10.1038/s41418-021-00922-9. Epub 2021 Dec 15. Cell Death Differ. 2022. PMID: 34912054 Free PMC article. Review.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Crawford N, Stott KJ, Sessler T, McCann C, McDaid W, Lees A, Latimer C, Fox JP, Munck JM, Smyth T, Shah A, Martins V, Lawler M, Dunne PD, Kerr EM, McDade SS, Coyle VM, Longley DB. Crawford N, et al. Mol Cancer Ther. 2021 Sep;20(9):1627-1639. doi: 10.1158/1535-7163.MCT-20-1050. Epub 2021 Aug 13. Mol Cancer Ther. 2021. PMID: 34389694 Free PMC article.
TRAIL signaling promotes entosis in colorectal cancer.
Bozkurt E, Düssmann H, Salvucci M, Cavanagh BL, Van Schaeybroeck S, Longley DB, Martin SJ, Prehn JHM. Bozkurt E, et al. J Cell Biol. 2021 Nov 1;220(11):e202010030. doi: 10.1083/jcb.202010030. Epub 2021 Sep 21. J Cell Biol. 2021. PMID: 34546352 Free PMC article.
The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB. Roberts JZ, et al. Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20. Cell Death Differ. 2020. PMID: 32313199 Free PMC article.
FLINO: a new method for immunofluorescence bioimage normalization.
Graf J, Cho S, McDonough E, Corwin A, Sood A, Lindner A, Salvucci M, Stachtea X, Van Schaeybroeck S, Dunne PD, Laurent-Puig P, Longley D, Prehn JHM, Ginty F. Graf J, et al. Bioinformatics. 2022 Jan 3;38(2):520-526. doi: 10.1093/bioinformatics/btab686. Bioinformatics. 2022. PMID: 34601553 Free PMC article.
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists.
Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Grinkevitch V, et al. Mol Cancer Ther. 2022 Apr 1;21(4):594-606. doi: 10.1158/1535-7163.MCT-21-0532. Mol Cancer Ther. 2022. PMID: 35086954 Free PMC article.
21 results