MR/P016693/1/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

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Subject: MR/P016693/1/MRC_/Medical Research Council/United - PubMed

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Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.

Scarpa M, Molloy C, Jenkins L, Strellis B, Budgett RF, Hesse S, Dwomoh L, Marsango S, Tejeda GS, Rossi M, Ahmed Z, Milligan G, Hudson BD, Tobin AB, Bradley SJ. Scarpa M, et al. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2107389118. doi: 10.1073/pnas.2107389118. Proc Natl Acad Sci U S A. 2021. PMID: 34893539 Free PMC article.

M₁ muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.

Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn J, Lindsley CW, Bradley SJ, Tobin AB. Dwomoh L, et al. Sci Signal. 2022 Nov 15;15(760):eabm3720. doi: 10.1126/scisignal.abm3720. Epub 2022 Nov 15. Sci Signal. 2022. PMID: 36378750 Free PMC article.

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