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A pharmacogenetics study of the human glucuronosyltransferase UGT1A4.
Benoit-Biancamano MO, Adam JP, Bernard O, Court MH, Leblanc MH, Caron P, Guillemette C. Benoit-Biancamano MO, et al. Pharmacogenet Genomics. 2009 Dec;19(12):945-54. doi: 10.1097/FPC.0b013e3283331637. Pharmacogenet Genomics. 2009. PMID: 19890225 Free PMC article.
Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.
Lévesque E, Bélanger AS, Harvey M, Couture F, Jonker D, Innocenti F, Cecchin E, Toffoli G, Guillemette C. Lévesque E, et al. J Pharmacol Exp Ther. 2013 Apr;345(1):95-101. doi: 10.1124/jpet.112.202242. Epub 2013 Feb 5. J Pharmacol Exp Ther. 2013. PMID: 23386248 Free PMC article. Clinical Trial.
The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure.
Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group. Court MH, et al. J Pharmacol Exp Ther. 2013 May;345(2):297-307. doi: 10.1124/jpet.112.202010. Epub 2013 Feb 13. J Pharmacol Exp Ther. 2013. PMID: 23408116 Free PMC article.