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Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Khan AO, Rodriguez-Romera A, Reyat JS, Olijnik AA, Colombo M, Wang G, Wen WX, Sousos N, Murphy LC, Grygielska B, Perrella G, Mahony CB, Ling RE, Elliott NE, Karali CS, Stone AP, Kemble S, Cutler EA, Fielding AK, Croft AP, Bassett D, Poologasundarampillai G, Roy A, Gooding S, Rayes J, Machlus KR, Psaila B. Khan AO, et al. Cancer Discov. 2023 Feb 6;13(2):364-385. doi: 10.1158/2159-8290.CD-22-0199. Cancer Discov. 2023. PMID: 36351055 Free PMC article.
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT, Smith AL, Godfrey L, Dopico-Fernandez AM, Denny N, Harman JR, Hamley JC, Jackson NE, Chahrour C, Riva S, Rice S, Kim J, Basrur V, Fermin D, Elenitoba-Johnson K, Roeder RG, Allis CD, Roberts I, Roy A, Geng H, Davies JOJ, Milne TA. Crump NT, et al. Nat Commun. 2023 Aug 25;14(1):5208. doi: 10.1038/s41467-023-40981-9. Nat Commun. 2023. PMID: 37626123 Free PMC article.
Processing single-cell RNA-seq datasets using SingCellaR.
Wang G, Wen WX, Mead AJ, Roy A, Psaila B, Thongjuea S. Wang G, et al. STAR Protoc. 2022 Apr 1;3(2):101266. doi: 10.1016/j.xpro.2022.101266. eCollection 2022 Jun 17. STAR Protoc. 2022. PMID: 35391938 Free PMC article.
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M, Ejaz A, Hua P, Rice S, Zhang W, Hentges LD, Fisher CA, Denny N, Schwessinger R, Yasara N, Roy NBA, Issa F, Roy A, Telfer P, Hughes J, Mettananda S, Higgs DR, Davies JOJ. Badat M, et al. Nat Commun. 2023 Apr 19;14(1):2238. doi: 10.1038/s41467-023-37604-8. Nat Commun. 2023. PMID: 37076455 Free PMC article.
CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies.
Bueno C, Barrera S, Bataller A, Ortiz-Maldonado V, Elliot N, O'Byrne S, Wang G, Rovira M, Gutierrez-Agüera F, Trincado JL, González-González M, Morgades M, Sorigué M, Bárcena P, Zanetti SR, Torrebadell M, Vega-Garcia N, Rives S, Mallo M, Sole F, Mead AJ, Roberts I, Thongjuea S, Psaila B, Juan M, Delgado J, Urbano-Ispizúa A, Ribera JM, Orfao A, Roy A, Menendez P. Bueno C, et al. Blood. 2022 Jul 7;140(1):38-44. doi: 10.1182/blood.2021014840. Blood. 2022. PMID: 35421218 Free PMC article.
In utero origin of myelofibrosis presenting in adult monozygotic twins.
Sousos N, Ní Leathlobhair M, Simoglou Karali C, Louka E, Bienz N, Royston D, Clark SA, Hamblin A, Howard K, Mathews V, George B, Roy A, Psaila B, Wedge DC, Mead AJ. Sousos N, et al. Nat Med. 2022 Jun;28(6):1207-1211. doi: 10.1038/s41591-022-01793-4. Epub 2022 May 30. Nat Med. 2022. PMID: 35637336 Free PMC article.
Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome.
Li S, Sok P, Xu K, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Metayer C, Ma X, Mueller BA, Roy A, Roberts I, Rabin KR, Brown AL, Lupo PJ, Wiemels JL, de Smith AJ. Li S, et al. Blood Adv. 2022 Jul 26;6(14):4132-4136. doi: 10.1182/bloodadvances.2022007098. Blood Adv. 2022. PMID: 35588500 Free PMC article. No abstract available.