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Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.
Maag D, Maxwell MJ, Hardesty DA, Boucher KL, Choudhari N, Hanno AG, Ma JF, Snowman AS, Pietropaoli JW, Xu R, Storm PB, Saiardi A, Snyder SH, Resnick AC. Maag D, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6. doi: 10.1073/pnas.1017831108. Epub 2011 Jan 10. Proc Natl Acad Sci U S A. 2011. PMID: 21220345 Free PMC article.