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Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver.
Sci Rep. 2015 Aug 6;5:12911. doi: 10.1038/srep12911.
Sci Rep. 2015.
PMID: 26246194
Free PMC article.
MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes.
Kurtz CL, Peck BC, Fannin EE, Beysen C, Miao J, Landstreet SR, Ding S, Turaga V, Lund PK, Turner S, Biddinger SB, Vickers KC, Sethupathy P.
Kurtz CL, et al.
Diabetes. 2014 Sep;63(9):3141-8. doi: 10.2337/db13-1015. Epub 2014 Apr 10.
Diabetes. 2014.
PMID: 24722248
Free PMC article.
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