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PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis.
Hsiao YT, Yoshida Y, Okuda S, Abe M, Mizuno S, Takahashi S, Nakagami H, Morishita R, Kamimura K, Terai S, Aung TM, Li J, Furihata T, Tang JY, Walsh K, Ishigami A, Minamino T, Shimizu I. Hsiao YT, et al. EMBO J. 2024 Nov;43(21):4846-4869. doi: 10.1038/s44318-024-00196-0. Epub 2024 Aug 19. EMBO J. 2024. PMID: 39160276 Free PMC article.
PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H. Sekine H, et al. Nat Metab. 2024 Jun;6(6):1108-1127. doi: 10.1038/s42255-024-01053-4. Epub 2024 May 31. Nat Metab. 2024. PMID: 38822028 Free PMC article.