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Evolved histone tail regulates 53BP1 recruitment at damaged chromatin.
Kelliher JL, Folkerts ML, Shen KV, Song W, Tengler K, Stiefel CM, Lee SO, Dray E, Zhao W, Koss B, Pannunzio NR, Leung JW. Kelliher JL, et al. Nat Commun. 2024 May 31;15(1):4634. doi: 10.1038/s41467-024-49071-w. Nat Commun. 2024. PMID: 38821984 Free PMC article.
Increased AID results in mutations at the CRLF2 locus implicated in Latin American ALL health disparities.
Rangel V, Sterrenberg JN, Garawi A, Mezcord V, Folkerts ML, Calderon SE, Garcia YE, Wang J, Soyfer EM, Eng OS, Valerin JB, Tanjasiri SP, Quintero-Rivera F, Seldin MM, Masri S, Frock RL, Fleischman AG, Pannunzio NR. Rangel V, et al. Nat Commun. 2024 Jul 27;15(1):6331. doi: 10.1038/s41467-024-50537-0. Nat Commun. 2024. PMID: 39068148 Free PMC article.
Evaluating the AID-induced mutation load in patients at-risk for certain blood cancers is critical in assessing disease severity and treatment options. We have developed a digital PCR (dPCR) assay that allows us to quantify mutations resulting from AID modification or DNA …
Evaluating the AID-induced mutation load in patients at-risk for certain blood cancers is critical in assessing disease severity and …
Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression.
Zocchi L, Mehta A, Wu SC, Wu J, Gu Y, Wang J, Suh S, Spitale RC, Benavente CA. Zocchi L, et al. Oncogenesis. 2020 Feb 18;9(2):25. doi: 10.1038/s41389-020-0210-7. Oncogenesis. 2020. PMID: 32071286 Free PMC article.
Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that drive these epigenetic …
Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor pr …