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Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil.
J Pharmacol Exp Ther. 2008 Aug;326(2):380-7. doi: 10.1124/jpet.108.137422. Epub 2008 May 2.
J Pharmacol Exp Ther. 2008.
PMID: 18456872
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.
Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME.
Blanton RM, et al.
J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8.
J Gerontol A Biol Sci Med Sci. 2013.
PMID: 23657971
Free PMC article.
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Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.
Blanton RM, Takimoto E, Lane AM, Aronovitz M, Piotrowski R, Karas RH, Kass DA, Mendelsohn ME.
Blanton RM, et al.
J Am Heart Assoc. 2012 Oct;1(5):e003731. doi: 10.1161/JAHA.112.003731. Epub 2012 Oct 25.
J Am Heart Assoc. 2012.
PMID: 23316302
Free PMC article.
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