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Akt2 regulates cardiac metabolism and cardiomyocyte survival.
DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. DeBosch B, et al. J Biol Chem. 2006 Oct 27;281(43):32841-51. doi: 10.1074/jbc.M513087200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16950770 Free PMC article.
Akt1 is required for physiological cardiac growth.
DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. DeBosch B, et al. Circulation. 2006 May 2;113(17):2097-104. doi: 10.1161/CIRCULATIONAHA.105.595231. Epub 2006 Apr 24. Circulation. 2006. PMID: 16636172