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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, Tahirovic S, Park JI, Prorok R, Mahon C, Liang CC, Shi J, Kim DJ, Sabelström H, Huang F, Di Paolo G, Simons M, Lewcock JW, Haass C. Schlepckow K, et al. EMBO Mol Med. 2020 Apr 7;12(4):e11227. doi: 10.15252/emmm.201911227. Epub 2020 Mar 10. EMBO Mol Med. 2020. PMID: 32154671 Free PMC article.
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A. Colombo AV, et al. Elife. 2021 Apr 13;10:e59826. doi: 10.7554/eLife.59826. Elife. 2021. PMID: 33845942 Free PMC article.
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation.
Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M; Alzheimer's Disease Neuroimaging Initiative (ADNI); Brendel M, Haass C, Franzmeier N. Ewers M, et al. EMBO Mol Med. 2020 Sep 7;12(9):e12308. doi: 10.15252/emmm.202012308. Epub 2020 Aug 10. EMBO Mol Med. 2020. PMID: 32790063 Free PMC article.