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Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia.
Hagemann N, Mohamud Yusuf A, Martiny C, Zhang X, Kleinschnitz C, Gunzer M, Kolesnick R, Gulbins E, Hermann DM. Hagemann N, et al. Basic Res Cardiol. 2020 Oct 14;115(6):64. doi: 10.1007/s00395-020-00823-x. Basic Res Cardiol. 2020. PMID: 33057972 Free PMC article.