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Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.
Chem Biol. 2011 May 27;18(5):601-7. doi: 10.1016/j.chembiol.2011.03.008.
Chem Biol. 2011.
PMID: 21609841
Free PMC article.
The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.
Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM Jr, Kelleher NL, Walsh CT.
Hollenhorst MA, et al.
J Am Chem Soc. 2010 Nov 10;132(44):15773-81. doi: 10.1021/ja1072367.
J Am Chem Soc. 2010.
PMID: 20945916
Free PMC article.
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