G0700656/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2009	2
2010	2
2011	1
2012	8
2013	4
2016	1
2017	2
2018	3
2019	4
2020	4
2021	2
2023	2
2024	0

1

Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.

Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J. Zhu H, et al. Science. 2023 Dec 22;382(6677):1404-1411. doi: 10.1126/science.adi9926. Epub 2023 Dec 21. Science. 2023. PMID: 38127736 Free PMC article.

2

Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.

Pal P, Taylor M, Lam PY, Tonelli F, Hecht CA, Lis P, Nirujogi RS, Phung TK, Yeshaw WM, Jaimon E, Fasimoye R, Dickie EA, Wightman M, Macartney T, Pfeffer SR, Alessi DR. Pal P, et al. Sci Adv. 2023 Dec 15;9(50):eadj1205. doi: 10.1126/sciadv.adj1205. Epub 2023 Dec 13. Sci Adv. 2023. PMID: 38091401 Free PMC article.

3

Small-Molecule Inhibitors of LRRK2.

Hatcher JM, Choi HG, Alessi DR, Gray NS. Hatcher JM, et al. Adv Neurobiol. 2017;14:241-264. doi: 10.1007/978-3-319-49969-7_13. Adv Neurobiol. 2017. PMID: 28353288 Review.

4

Brain Penetrant LRRK2 Inhibitor.

Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Choi HG, et al. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662. doi: 10.1021/ml300123a. Epub 2012 Jun 18. ACS Med Chem Lett. 2012. PMID: 23066449 Free PMC article.

5

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.

Taylor M, Alessi DR. Taylor M, et al. Curr Opin Cell Biol. 2020 Apr;63:102-113. doi: 10.1016/j.ceb.2020.01.001. Epub 2020 Feb 7. Curr Opin Cell Biol. 2020. PMID: 32036294 Free PMC article. Review.

6

A meeting of minds: overcoming roadblocks in the development of therapies for neurodegenerative disorders.

Muqit MM, Alessi DR. Muqit MM, et al. EMBO Mol Med. 2009 Jun;1(3):139-41. doi: 10.1002/emmm.200900021. EMBO Mol Med. 2009. PMID: 20049713 Free PMC article. No abstract available.

7

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Steger M, et al. Elife. 2017 Nov 10;6:e31012. doi: 10.7554/eLife.31012. Elife. 2017. PMID: 29125462 Free PMC article.

8

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.

Kalogeropulou AF, Freemantle JB, Lis P, Vides EG, Polinski NK, Alessi DR. Kalogeropulou AF, et al. Biochem J. 2020 Nov 27;477(22):4397-4423. doi: 10.1042/BCJ20200458. Biochem J. 2020. PMID: 33135724 Free PMC article.

9

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

Malik AU, Karapetsas A, Nirujogi RS, Mathea S, Chatterjee D, Pal P, Lis P, Taylor M, Purlyte E, Gourlay R, Dorward M, Weidlich S, Toth R, Polinski NK, Knapp S, Tonelli F, Alessi DR. Malik AU, et al. Biochem J. 2021 Feb 12;478(3):553-578. doi: 10.1042/BCJ20200937. Biochem J. 2021. PMID: 33459343 Free PMC article.

10

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease.

Lewis PA, Alessi DR. Lewis PA, et al. Biochem Soc Trans. 2012 Oct;40(5):1039-41. doi: 10.1042/BST20120178. Biochem Soc Trans. 2012. PMID: 22988861 Review.

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