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RAS in pancreatic cancer.
Lanfredini S, Thapa A, O'Neill E. Lanfredini S, et al. Biochem Soc Trans. 2019 Aug 30;47(4):961-972. doi: 10.1042/BST20170521. Epub 2019 Jul 24. Biochem Soc Trans. 2019. PMID: 31341034 Review.
RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E. Papaspyropoulos A, et al. Nat Commun. 2018 Jan 30;9(1):424. doi: 10.1038/s41467-017-02786-5. Nat Commun. 2018. PMID: 29382819 Free PMC article.
TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.
Eyres M, Lanfredini S, Xu H, Burns A, Blake A, Willenbrock F, Goldin R, Hughes D, Hughes S, Thapa A, Vavoulis D, Hubert A, D'Costa Z, Sabbagh A, Abraham AG, Blancher C, Jones S, Verrill C, Silva M, Soonawalla Z, Maughan T, Schuh A, Mukherjee S, O'Neill E. Eyres M, et al. Gastroenterology. 2021 Aug;161(2):653-668.e16. doi: 10.1053/j.gastro.2021.04.044. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33915173
RASSF1A is required for the maintenance of nuclear actin levels.
Chatzifrangkeskou M, Pefani DE, Eyres M, Vendrell I, Fischer R, Pankova D, O'Neill E. Chatzifrangkeskou M, et al. EMBO J. 2019 Aug 15;38(16):e101168. doi: 10.15252/embj.2018101168. Epub 2019 Jun 7. EMBO J. 2019. PMID: 31414556 Free PMC article.
Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2).
Strauss VY, Shaw R, Virdee PS, Hurt CN, Ward E, Tranter B, Patel N, Bridgewater J, Parsons P, Radhakrishna G, O'Neill E, Sebag-Montefiore D, Hawkins M, Corrie PG, Maughan T, Mukherjee S. Strauss VY, et al. BMC Cancer. 2019 Feb 4;19(1):121. doi: 10.1186/s12885-019-5307-z. BMC Cancer. 2019. PMID: 30717707 Free PMC article. Clinical Trial.