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Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
Moreira-Teixeira L, Stimpson PJ, Stavropoulos E, Hadebe S, Chakravarty P, Ioannou M, Aramburu IV, Herbert E, Priestnall SL, Suarez-Bonnet A, Sousa J, Fonseca KL, Wang Q, Vashakidze S, Rodríguez-Martínez P, Vilaplana C, Saraiva M, Papayannopoulos V, O'Garra A. Moreira-Teixeira L, et al. Nat Commun. 2020 Nov 4;11(1):5566. doi: 10.1038/s41467-020-19412-6. Nat Commun. 2020. PMID: 33149141 Free PMC article.
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Bartlett NW, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SL. Toussaint M, et al. Nat Med. 2017 Jun;23(6):681-691. doi: 10.1038/nm.4332. Epub 2017 May 1. Nat Med. 2017. PMID: 28459437 Free PMC article.