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Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.
Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA. Schlott AC, et al. Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9. Cell Chem Biol. 2019. PMID: 31080074 Free PMC article.
Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.
Pandey R, Abel S, Boucher M, Wall RJ, Zeeshan M, Rea E, Freville A, Lu XM, Brady D, Daniel E, Stanway RR, Wheatley S, Batugedara G, Hollin T, Bottrill AR, Gupta D, Holder AA, Le Roch KG, Tewari R. Pandey R, et al. Cell Rep. 2020 Feb 11;30(6):1883-1897.e6. doi: 10.1016/j.celrep.2020.01.033. Cell Rep. 2020. PMID: 32049018 Free PMC article.
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
Knuepfer E, Wright KE, Kumar Prajapati S, Rawlinson TA, Mohring F, Koch M, Lyth OR, Howell SA, Villasis E, Snijders AP, Moon RW, Draper SJ, Rosanas-Urgell A, Higgins MK, Baum J, Holder AA. Knuepfer E, et al. PLoS Pathog. 2019 Jun 11;15(6):e1007809. doi: 10.1371/journal.ppat.1007809. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31185066 Free PMC article.
Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission.
Zeeshan M, Shilliday F, Liu T, Abel S, Mourier T, Ferguson DJP, Rea E, Stanway RR, Roques M, Williams D, Daniel E, Brady D, Roberts AJ, Holder AA, Pain A, Le Roch KG, Moores CA, Tewari R. Zeeshan M, et al. PLoS Pathog. 2019 Oct 10;15(10):e1008048. doi: 10.1371/journal.ppat.1008048. eCollection 2019 Oct. PLoS Pathog. 2019. PMID: 31600347 Free PMC article.
14 results