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A small molecule inhibitor prevents gut bacterial genotoxin production.
Volpe MR, Velilla JA, Daniel-Ivad M, Yao JJ, Stornetta A, Villalta PW, Huang HC, Bachovchin DA, Balbo S, Gaudet R, Balskus EP. Volpe MR, et al. Nat Chem Biol. 2023 Feb;19(2):159-167. doi: 10.1038/s41589-022-01147-8. Epub 2022 Oct 17. Nat Chem Biol. 2023. PMID: 36253549 Free PMC article.
Structural basis of colibactin activation by the ClbP peptidase.
Velilla JA, Volpe MR, Kenney GE, Walsh RM Jr, Balskus EP, Gaudet R. Velilla JA, et al. Nat Chem Biol. 2023 Feb;19(2):151-158. doi: 10.1038/s41589-022-01142-z. Epub 2022 Oct 17. Nat Chem Biol. 2023. PMID: 36253550 Free PMC article.