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Human cartilage model of the precocious osteoarthritis-inducing COL2A1 p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II.
Yammine KM, Abularach SM, Xiong M, Kim SY, Bikovtseva AA, Butty VL, Schiavoni RP, Bateman JF, Lamandé SR, Shoulders MD. Yammine KM, et al. bioRxiv [Preprint]. 2024 Nov 9:2024.11.07.622468. doi: 10.1101/2024.11.07.622468. bioRxiv. 2024. PMID: 39574595 Free PMC article. Preprint.