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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.
Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson WL, Yoneyama Y, Chaturvedi P, Zorn AM, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers RP, Subramanian GM, Hwa V, Takebe T. Kimura M, et al. Cell. 2022 Oct 27;185(22):4216-4232.e16. doi: 10.1016/j.cell.2022.09.031. Epub 2022 Oct 13. Cell. 2022. PMID: 36240780 Free PMC article.
Human liver model systems in a dish.
Thompson WL, Takebe T. Thompson WL, et al. Dev Growth Differ. 2021 Jan;63(1):47-58. doi: 10.1111/dgd.12708. Epub 2021 Feb 2. Dev Growth Differ. 2021. PMID: 33423319 Free PMC article. Review.
Organogenesis in vitro.
Iwasawa K, Takebe T. Iwasawa K, et al. Curr Opin Cell Biol. 2021 Dec;73:84-91. doi: 10.1016/j.ceb.2021.06.007. Epub 2021 Aug 2. Curr Opin Cell Biol. 2021. PMID: 34352726 Free PMC article. Review.
Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids.
Miao Y, Tan C, Pek NM, Yu Z, Iwasawa K, Kechele DO, Sundaram N, Pastrana-Gomez V, Kishimoto K, Yang MC, Jiang C, Tchieu J, Whitsett JA, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen YW, Guo M, Gu M. Miao Y, et al. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.577460. doi: 10.1101/2024.02.06.577460. bioRxiv. 2024. PMID: 38370768 Free PMC article. Preprint.
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.
Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T. Kawakami E, et al. Cell Stem Cell. 2023 Oct 5;30(10):1315-1330.e10. doi: 10.1016/j.stem.2023.09.001. Cell Stem Cell. 2023. PMID: 37802037 Free PMC article.
ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH.
Liu YJ, Kimura M, Li X, Sulc J, Wang Q, Rodríguez-López S, Scantlebery AML, Strotjohann K, Gallart-Ayala H, Vijayakumar A, Myers RP, Ivanisevic J, Houtkooper RH, Subramanian GM, Takebe T, Auwerx J. Liu YJ, et al. J Hepatol. 2024 Aug 22:S0168-8278(24)02484-X. doi: 10.1016/j.jhep.2024.08.009. Online ahead of print. J Hepatol. 2024. PMID: 39181211 Free article.
30 results